The general purpose of the Biostatistics and Bioinformatics Core (Core 3), is to provide comprehensive support in the areas of biostatistics and bioinformatics for all research projects, developmental and career development programs, and other cores of the UCLA Brain SPORE. Core 3 comprises multiple faculty members from the departments of Biostatistics, Biomathematics, and Department of Molecular, Cell and Developmental Biology, and staff statisticians and bioinformaticians.
Faculty members include nationally respected biostatisticians and bioinformaticians with broad expertise from general biostatistics, design and analysis of clinical trials, to analysis and interpretation of high-dimensional tissue arrays and gene expression data that are needed by the SPORE research projects. Collectively and individually, the members have participated in hundreds of studies involving diverse aspects of cancer research especially translational research. They have experience working in large centers and have served on NIH study sections and review committees.
The Core’s biostatistics/bioinformatics faculty and staff are actively involved in UCLA Jonsson Comprehensive Cancer Center (JCCC) current projects and have an established history of productive collaborations with the SPORE investigators. Core 3 has been working closely with the Brain SPORE investigators to provide support on study design, statistical analysis, and bioinformatics analysis.
Areas of support include:
- General biostatistics, design and analysis of clinical trials
- Collaboration on experimental designs
- Bioinformatics analyses including transcriptomes, exomes, and DNA Methylation analysis
- Collaboration on data management support
- Collaboration on manuscript preparation and presentation and interpretation of study results
- Collaboration on new grant applications
- Advice and consultation to the JCCC Internal Scientific Review Committee in the scientific reviews of clinical trials
- Advice and consultation to the JCCC Data Safety Monitoring Board (DSMB) for clinical trials
- Education for SPORE members in study design, data collection, and statistical methods for basic science, translational, and clinical studies