Dr. Matteo Pellegrini is a biophysicist who has served on the UCLA Life Sciences Division faculty since he joined the Department of Molecular, Cell and Developmental Biology in 2005.
Dr. Pellegrini earned his B.A. in Physics at Columbia University and his Ph.D. in Physics at Stanford. He was a postdoctoral fellow at UCLA, where he worked on computational biology. Following his postdoctoral studies, Dr. Pellegrini co-founded a start-up company and later worked for the pharmaceutical company, Merck, before returning to UCLA.
His laboratory research centers on the development of novel computational approaches to analyze large-scale genomic data. The Pellegrini group was instrumental in the development of whole genome bisulfite sequencing to measure the methylation status of nearly every cytosine in the genome.
Dr. Pelligrini's present focus is on data produced using the latest generation of high-throughput sequencers. Today the Pellegrini group is developing suites of tools for the analysis of high-throughput sequencing data such as methC-seq, RNA-seq, ChIP-seq and Chromatin Conformation Capture seq. These approaches have been used in many settings, including human and mouse studies in multiple tissues such as skin, blood, adipose and placenta as well as tumors.