Biostatistics, Analytical Support & Evaluation (BASE)

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Service Request

Requests to BASE for consulting services to Cancer Center investigators are initiated by email to lindu@ucla.edu with a completed BASE Unit Consultation Request Form.

Drop-In Consulting

No appointment necessary for drop-in consultations. Drop-ins are welcome from 12:00 p.m. to 1:00 p.m. every Friday.

Location: School of Public Health, Room 26-070
Email: lindu@ucla.edu
Phone: 310-206-1290

Contact information

Director: Gang Li, Ph.D.

Mailing Address

650 Charles E. Young Drive
CHS 26-070
Los Angeles, CA 90095-1772
 

Telephone: (310) 206-1290
Fax: (310) 267-2611
Email: lindu@ucla.edu

Primary Services

The mission of BASE is to provide statistical analysis and study design services to the UCLA Cancer Center community.

Biostatistical Study Support

BASE serves as the biostatistical and biomathematical resource for UCLA's Jonsson Comprehensive Cancer Center (JCCC) investigators in the areas of basic science, translational and clinical research design, data analysis and modeling, computing, and data management. In addition to standard statistical expertise, BASE can provide expert statistical collaboration on topics including pharmacokinetics, tissue array, clinical trials, microarray analysis, imaging analysis and proteomic analysis.

Guidance in Grant Preparation

BASE faculty can assist individual Cancer Center investigators in grant preparation. We can provide general guidance in terms of study design (experimental design, measurement, etc), sample size calculations and development of statistical analysis sections. In addition to assistance with grant preparation, BASE faculty are generally available to serve as co-investigators on grant applications and can provide long term collaboration for funded projects.

Details of BASE Unit Services

Long-Term Study Collaboration

Collaboration on projects from inception (typically at the grant preparation stage) through final manuscript submissions. For this we can provide assistance with the grant preparation, study planning, data management oversight data analytic support and collaboration on manuscript preparation. Typically for long-term collaborations BASE faculty and staff will be involved on the grant application (or can be added to funded projects) with percent effort funding appropriate to their project responsibilities.

Short-term Consulting

Provides a stable resource of productive biostatistical and biomathematical faculty and staff capable of short-term consulting with JCCC members in specific program areas. Short-term consulting typically consists of at most five hours of consultation with data analysis and manuscript preparation. Large analytic projects will typically require funding support for the BASE member(s) providing assistance.

Other BASE Unit Functions

  • BASE members provide critical expertise to protocol review and approval functions of the Internal Scientific Peer Review Committee (ISPRC), Data Safety and Monitoring Board (DSMB), the Internal Quality Assurance Committee and the Seed Grant Review Committee.
  • BASE faculty are available for assistance with TRIO-US trials
  • Develops graduate student participation in cancer-related studies supervised by BASE and provide training to fellows and faculty in the design and conduct of research.
  • Assists JCCC and other specialized centers in their research and reporting functions.
  • Providing statistics short courses and seminars to interested groups within the JCCC

Joint Partnership with JCCC Shared Resources

The JCCC Genomics/UCLA Clinical Microarray Core (CMC) and BASE are pleased to announce a formal strategic partnership. This partnership will significantly strengthen JCCC's next generation sequencing/Microarray capability. Under this agreement, CMC will perform the wet-lab sequencing/microarray and initial/standardized data analysis whereas BASE will perform the advanced/customized data analysis. Please visit the JCCC Genomics shared resource.

Access Priorities

Biostatistical support is available to all Cancer Center members and their laboratories. Peer-reviewed funded research projects of JCCC investigators represent the highest priority. Short-term tasks of interest to individual investigators that do not have available funding for statistical co-investigators are given some support on a first-come, first-served basis.

Recharge Rates

An estimate of project costs will be provided after the initial consultation meeting. JCCC members will receive 5 percent discounted rate.

Primary BASE faculty contact for JCCC research programs

JCCC research programs BASE SR members
Cancer and Stem Cell Biology Program Robert Elashoff
Cancer Molecular Imaging Program Gang Li
Cancer Nanotechnology Program Dontalo Telesca
Gene Regulation Program David Elashoff
Healthy and At-Risk Populations Program Kate Crespi
Patients and Survivors Program Kate Crespi
Signal Transduction and Therapeutics Program Ning Li
Tumor Immunology Program Xiaoyan Wang

Selected projects supported by BASE

PI Trial name Website link
Antoni Ribas Genetic Re-programming of Stem Cells to Fight Cancer https://bit.ly/2OgkEhz
Linda Liau UCLA SPORE in Brain Cancer https://bit.ly/2OdkLKI
Robert Chin A Phase II Trial of Induction Chemotherapy Followed by Attenuated Chemoradiotherapy for Locally Advanced Head and Neck Squamous Cell Carcinoma Associated with Human Papillomavirus (HPV)  
Jonathan Goldman A Phase 1b/2 Randomized, Open-Label Study of Niraparib Monotherapy or Niraparib Plus Temozolomide Versus Best Supportive Care as Maintenance Therapy in Patients with Extensive-Stage Small Cell Lung Cancer that had a Complete or Partial Response to Platinum-Based First-Line Chemotherapy (TRIO-US L-06)  
Avrum Spira, Denise Aberle, Steven Dubinett, David Elashoff, Marc Lenburg The Boston University-UCLA Lung Cancer Biomarker Development Laboratory https://bit.ly/2E6GyyN
Tim Cloughesy, Robert Prins FDG PET response clinical trial