No appointment necessary for drop-in consultations. Drop-ins are welcome from 12:00 p.m. to 1:00 p.m. every Friday.
Location: School of Public Health, Room 26-070
Director: Gang Li, Ph.D.Mailing Address
650 Charles E. Young Drive
Telephone: (310) 206-1290
The mission of BASE is to provide statistical analysis and study design services to the UCLA Cancer Center community.
Biostatistical Study Support
BASE serves as the biostatistical and biomathematical resource for UCLA's Jonsson Comprehensive Cancer Center (JCCC) investigators in the areas of basic science, translational and clinical research design, data analysis and modeling, computing, and data management. In addition to standard statistical expertise, BASE can provide expert statistical collaboration on topics including pharmacokinetics, tissue array, clinical trials, microarray analysis, imaging analysis and proteomic analysis.
Guidance in Grant Preparation
BASE faculty can assist individual Cancer Center investigators in grant preparation. We can provide general guidance in terms of study design (experimental design, measurement, etc), sample size calculations and development of statistical analysis sections. In addition to assistance with grant preparation, BASE faculty are generally available to serve as co-investigators on grant applications and can provide long term collaboration for funded projects.
Details of BASE Unit Services
Long-Term Study Collaboration
Collaboration on projects from inception (typically at the grant preparation stage) through final manuscript submissions. For this we can provide assistance with the grant preparation, study planning, data management oversight data analytic support and collaboration on manuscript preparation. Typically for long-term collaborations BASE faculty and staff will be involved on the grant application (or can be added to funded projects) with percent effort funding appropriate to their project responsibilities.
Provides a stable resource of productive biostatistical and biomathematical faculty and staff capable of short-term consulting with JCCC members in specific program areas. Short-term consulting typically consists of at most five hours of consultation with data analysis and manuscript preparation. Large analytic projects will typically require funding support for the BASE member(s) providing assistance.
Other BASE Unit Functions
- BASE members provide critical expertise to protocol review and approval functions of the Internal Scientific Peer Review Committee (ISPRC), Data Safety and Monitoring Board (DSMB), the Internal Quality Assurance Committee and the Seed Grant Review Committee.
- BASE faculty are available for assistance with TRIO-US trials
- Develops graduate student participation in cancer-related studies supervised by BASE and provide training to fellows and faculty in the design and conduct of research.
- Assists JCCC and other specialized centers in their research and reporting functions.
- Providing statistics short courses and seminars to interested groups within the JCCC
Joint Partnership with JCCC Shared Resources
The JCCC Genomics/UCLA Clinical Microarray Core (CMC) and BASE are pleased to announce a formal strategic partnership. This partnership will significantly strengthen JCCC's next generation sequencing/Microarray capability. Under this agreement, CMC will perform the wet-lab sequencing/microarray and initial/standardized data analysis whereas BASE will perform the advanced/customized data analysis. Please visit the JCCC Genomics shared resource.
Biostatistical support is available to all Cancer Center members and their laboratories. Peer-reviewed funded research projects of JCCC investigators represent the highest priority. Short-term tasks of interest to individual investigators that do not have available funding for statistical co-investigators are given some support on a first-come, first-served basis.
An estimate of project costs will be provided after the initial consultation meeting. JCCC members will receive 5 percent discounted rate.
Selected projects supported by BASE
|PI||Trial name||Website link|
|Antoni Ribas||Genetic Re-programming of Stem Cells to Fight Cancer||https://bit.ly/2OgkEhz|
|Linda Liau||UCLA SPORE in Brain Cancer||https://bit.ly/2OdkLKI|
|Robert Chin||A Phase II Trial of Induction Chemotherapy Followed by Attenuated Chemoradiotherapy for Locally Advanced Head and Neck Squamous Cell Carcinoma Associated with Human Papillomavirus (HPV)|
|Jonathan Goldman||A Phase 1b/2 Randomized, Open-Label Study of Niraparib Monotherapy or Niraparib Plus Temozolomide Versus Best Supportive Care as Maintenance Therapy in Patients with Extensive-Stage Small Cell Lung Cancer that had a Complete or Partial Response to Platinum-Based First-Line Chemotherapy (TRIO-US L-06)|
|Lara Ray||A Randomized Controlled Clinical Trial of the Neuroimmune Modulator Ibudilast for the Treatment of Alcohol Use Disorder|
|Avrum Spira, Denise Aberle, Steven Dubinett, David Elashoff, Marc Lenburg||The Boston University-UCLA Lung Cancer Biomarker Development Laboratory||https://bit.ly/2E6GyyN|
|Tim Cloughesy, Robert Prins||FDG PET response clinical trial|