Signal Transduction and Therapeutics Program

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Dr. Richard Finn Dr. Heather Christofk

Director

Richard Finn, M.D.

Contact via email

Co-director

Heather Christofk, Ph.D.

Contact via email

Overview

The Signal Transduction and Therapeutics Program investigates the multiple signaling pathways and related genetic alterations that occur during formation of cancer cells and tumors. Signal transduction pathway studies are carried out by employing phospho-protein analysis, cell cycle, gene expression studies and chemical genetics approaches.

For more information, please visit the research program's website at http://www.sttprogram.ucla.edu/

Goals

  1. To understand signal transduction events in the development of cancer by identifying new genes involved in cell signaling pathways
  2. To develop new methods to detect changes in signaling events
  3. To develop inhibitors of signal transduction that could lead to new anti-cancer therapies

Meetings and Events

  • Quarterly meetings for new members to present their research
  • Quarterly seminars given by members of the program area
  • Quarterly seminars given by invited speakers from outside institutions
  • Twice a year mini-symposia on Signal Transduction and Cancer Therapeutics

Leadership

Dr. Richard Finn, director of the Signal Transduction and Therapeutics Program, was an undergraduate at UCLA, where he was involved with early laboratory studies investigating the HER2 oncogene and the development of monoclonal antibodies to this target in breast cancer with Dr Dennis Slamon. He participated in the pre-clinical studies that defined the clinical candidate that eventually humanized and became the FDA approved agent trastuzumab (Herceptin). He went on to medical school at USC then returned to UCLA for his clinical training in internal medicine, and then hematology and oncology. His research interests are focused in the development of targeted therapeutics for solid tumors across histologies to support the larger efforts of the department.

Dr. Heather Christofk, co-director of the Signal Transduction and Therapeutics Program, is focused on metabolic transitions in cells, which coincide with important cellular processes such as differentiation, malignant transformation and virus infection. She is particularly interested in what regulates metabolic transitions in normal and disease states, how viruses rewire host cell metabolism to meet their biosynthetic needs and how the metabolic state of a cell contributes to cell identity and functionality. By elucidating metabolic reprogramming mechanisms, she hopes to identify new cancer treatment strategies.

Upcoming Events

The following list is for upcoming events and seminars of notable interest to the Signal Transduction and Therapeutics Program and its members. This calendar is updated automatically.

For a list of all upcoming JCCC events (including other research programs, patients and survivors, and the UCLA Jonsson Cancer Center Foundation), please visit the Events Calendar.