Two committees oversee clinical research within UCLA's Jonsson Comprehensive Cancer Center (JCCC), the Internal Scientific Peer Review Committee and Data Safety Monitoring Board. Proper conduct of clinical trials in oncology is ensured by the Internal Quality Assurance Program, established in 1986.
Internal Scientific Peer Review Committee
The Internal Scientific Peer Review Committee (ISPRC) reviews clinical oncology protocols conducted by JCCC investigators. Drs. John Glaspy and Albert Lai serve as Co-Chairmen of the ISPRC. Under their direction, the committee reviews the required elements of the clinical protocol, statistical applications and other factors such as adequate research staffing, any competing trials, well-constituted data collection forms and utilization of other JCCC resources.
ISPRC application forms are available for download below. Only electronic submissions are accepted.
- Instructions for Electronic New Study Submissions using CAFE (Comprehensive Ancillary Forms Engine)
- Old Study Submission Form
- Old Study Submission Form Instructions
- ISPRC Meeting Schedule (2020)
Data Safety Monitoring Board
In response to the National Cancer Institute mandate, the JCCC Data Safety Monitoring Board (DSMB) was constituted in January 2001 and meets monthly. The JCCC DSMB reviews all Serious Adverse Events (SAEs) occurring in JCCC protocols. In addition, the JCCC DSMB serves as the DSMB for institutional research studies at UCLA that do not have an external DSMB.
The JCCC DSMB helps to ensure that adequate safety monitoring will be carried out for all cancer interventional trials offered at the JCCC. The DSMB oversees the implementation of the data monitoring plans approved by ISPRC and on file with the JCCC. The chairman of the JCCC DSMB is Dr. Sven De Vos.
- Serious Adverse Event Reporting Algorithm
- JCCC DSMB Serious Adverse Event Reporting Form
- Single Subject Exception Request Form
- DSMB Meeting Schedule (2020)
Quorum permitted, DSMB meetings are held on the first Tuesday of every month except when the meeting day is after a holiday. The deadline for submissions is two weeks prior to each meeting as noted in the DSMB Meeting Schedule (2020) link above.
Internal Quality Assurance Program
JCCC has had a long-standing Internal Quality Assurance Program (IQAP), beginning in 1986, to ensure proper conduct of clinical trials in oncology and, in so doing, safeguarding the rights and welfare of the study subjects. The internal compliance program is responsible for establishing an effective mechanism to promote proper adherence to all applicable local, state and federal laws, as well as specific program or cooperative group requirements by all researchers involved in oncology clinical research.
The IQAP includes:
- Performance of prospective monitoring and retrospective auditing of active trials to ensure regulatory and protocol compliance
- Ensuring proper patient management per protocol and to ensure patient safety
- Assisting principal investigators, sub-investigators and all clinical trial study team members by consulting on problems identified during any monitoring or auditing reviews
- Educating and continually updating the research community regarding clinical research requirements
Please submit all applications to the Office of Regulatory Compliance via email (submission link). Only electronic submissions are accepted.
UCLA Jonsson Comprehensive Cancer Center
Office of Regulatory Compliance
Phone: (310) 794-8742
Fax: (310) 794-8772
Interim Administrative Director, JCCC ORC
Allan Derrick Udarbe
Manager, Office of Regulatory Compliance
Regulatory Affairs Reporting Coordinator