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UCLA physicians, scientists to present on latest cancer research advancements in immunotherapy, genomics at AACR annual meeting

Post Date:April 03, 2018 9:00 AM

Scientists at the UCLA Jonsson Comprehensive Cancer Center (JCCC) will be presenting on the most recent advancements in cancer research at the 109th American Association for Cancer Research (AACR) annual meeting. The annual event takes place at the McCormick Convention Center in Chicago from April 14 to April 18. UCLA JCCC researchers will highlight the latest developments in the basic, translational, clinical, and prevention-focused research in the field.

The conference brings together more than 22,000 scientists, clinicians, advocates and industry luminaries from institutions around the world to discuss significant advances in cancer research.

More than 30 abstracts, sessions and events at AACR 2018 will feature members of the Jonsson Cancer Center. Below are UCLA-led symposia, presentations and other events where JCCC researchers are speaking or appearing.

For the complete AACR 2018 Annual Meeting program, please visit their iPlanner.

Major symposia

Defining and Addressing the Heterogeneity of Hepatocellular Carcinoma (HCC)
"Bridging the gap between science and treatment in HCC"

April 15, 2018, 1:00 p.m. to 2:45 p.m.
Room N228 - McCormick Place North (Level 2)

  • Faculty: Richard Finn, M.D., assistant professor in medicine, UCLA Jonsson Comprehensive Cancer Center member

The symposium will review and present emerging data on our understanding of the various molecular subtypes of HCC and how they will impact the development of new agents in HCC, from small molecules to immunotherapy based approaches.

Genomic/Functional Screens to Predict Response/Resistance to Immunotherapy
"Immune evasion mechanisms in melanoma resistant to targeted- and/or immunotherapy"

April 17, 2018, 1:00 p.m. to 2:45 p.m.
N Hall B (Plenary Hall) - McCormick Place North (Level 3)

  • Faculty: Willy Hugo, Lu Sun, Marco Piva, Shirley Lomeli, Chunying Song, Antoni Ribas, Roger Lo. UCLA, Los Angeles, CA

This session will explore how analysis of the cancer genome in immunotherapy-treated patients, and functional genomic screens in mouse models can be used to identify new targets and resistance mechanisms that govern the immune response to cancer.

Mini symposia

Endogenous and Exogenous Factors in Cancer Risk and Mortality
"Insulin resistance and long-term cancer-specific and all-cause mortality: The Women’s Health Initiative"

April 17, 2018, 3:00 p.m. to 5:00 p.m.
Room S504 - McCormick Place South (Level 5)

  • Faculty: Kathy Pan, M.D., physician in hematology and medical oncology at Harbor-UCLA Medical Center

Metabolism: Emerging Concepts and Therapy
"Identification of new modulators of nucleotide metabolism and replication stress in PDAC"

April 17, 2018, 3:00 p.m. to 5:00 p.m.
Room S105 - McCormick Place South (Level 1)

  • Faculty: Evan Abt, Amanda Dann, Thuc Le, Joe Capri, Chloe Cheng, Juna Yi, Soumya Poddar, Woosuk Kim, Timothy Donahue, Caius Radu. UCLA, Los Angeles, CA

Emerging Immunotherapy Targets and Combination Strategies to Overcome Treatment Resistance
"Targeting epithelial membrane protein 2 on breast tumor cells with a fusion construct containing the serine protease granzyme B"

April 17, 2018, 3:00 p.m. to 5:00 p.m.
Room S406 (Vista Ballroom) - McCormick Place South (Level 4)

  • Faculty: Khalid Mohamedali, Shabnam Mohandessi, Lawrence Cheung, Michael Rosenblum, Madhuri Wadehra. The University of Texas M.D. Anderson Cancer Center, Houston, TX; UCLA David Geffen School of Medicine, Los Angeles, CA

Plenary sessions

Fundamental and Applied Cancer Immunology
"Overcoming resistance to PD-1 blockade"

April 17, 2018, 9:35 a.m. to 10:00 a.m.
N Hall B (Plenary Hall) - McCormick Place North (Level 3)

  • Faculty: Antoni Ribas, M.D., Ph.D., professor in medicine and director if the Tumor Immunology Program at UCLA’s Jonsson Comprehensive Cancer Center

Educational sessions

Tumor Immunology and Immunotherapy for Nonimmunologists: Understanding and Intervening in the Immune Response from Premalignancy to Metastatic Disease
"The immune landscape in premalignancy"

April 14, 2018, 8:00 a.m. to 10 a.m.
N Hall C - McCormick Place North (Level 1)

  • Faculty: Steven Dubinett, M.D., professor in medicine and pathology and director of the UCLA Jonsson Comprehensive Cancer Center Lung Cancer Research Program

In Vivo Monitoring of Immunotherapy Responses
"ImmunoPET for in vivo monitoring of immunotherapy responses"

April 16, 2018, 10:30 a.m. to 12:15 p.m.
N Hall C - McCormick Place North (Level 1)

  • Faculty: Anna Wu, Ph.D., professor in molecular and medical pharmacology and in pathology and laboratory medicine at the David Geffen School of Medicine

This session discusses how immune responses raised by cancer immunotherapies such as immune checkpoint inhibitors can be properly monitored in this session.

Tumor, Blood, and Germline Biomarkers of the Radiation Response
"Defining the radiation 'response' using germline microRNA based biomarkers"

April 18, 2018, 10:15 a.m. to 12 p.m.
Room N228 - McCormick Place North (Level 2)

  • Faculty: Joanne Weidhaas, M.D., Ph.D., professor in radiation oncology and director of the Molecular and Cellular Oncology program

In this session, Weidhaas will discuss the meaning of a “radiation response,” and the role of biomarkers in predicting this response, considering toxicity, tumor control, and systemic cancer control. She will also discuss in depth several different approaches to both predict and evaluate a patient’s radiation response.

Awards and lectures

Sixth Annual AACR-CRI Lloyd J. Old Award in Cancer Immunology
April 17, 2018, 3:30 p.m. to 4:15 p.m.
Room S100 (Grand Ballroom) - McCormick Place South (Level 1)

The AACR-CRI Lloyd J. Old Award in Cancer Immunology was established to honor the memory of the late Lloyd J. Old and will recognize Ribas, whose outstanding and innovative research in cancer immunology has had a far-reaching impact on the cancer field.

Antoni Ribas, M.D., Ph.D., professor in medicine and director if the Tumor Immunology Program at UCLA’s Jonsson Comprehensive Cancer Center. He will present his lecture, "Genetic engineering of anticancer immune responses."

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