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JCCC Research Seminar featuring David Nathanson

Development of brain penetrant EGFR inhibitors for malignant glioma

Presented by
David Nathanson, Ph.D.
Assistant Professor
Department of Molecular and Medical Pharmacology

Dr. David Nathanson’s laboratory focuses on glioblastoma (GBM), the most lethal form of brain cancer. The Nathanson lab has specific interest in investigating altered signal transduction networks and the interplay with GBM metabolism, with a strong emphasis on metabolic phenotyping of specific oncogenic signals using non-invasive positron emission tomography (PET). In addition, they are interested in understanding the mechanisms of resistance to targeted therapies in GBM, including intrinsic adaptive signaling and the role of tumor heterogeneity. Their ultimate goal is to develop new strategies 1) to use metabolic PET to non-invasively measure oncogene activity for drug development/dosing and 2) to predict and exploit tumor adaptation to targeted therapies.

Light lunch served

Sponsored by the UCLA Jonsson Comprehensive Cancer Center Cancer Molecular Imaging, Nanotechnology and Theranostics research program

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